Polyradiculoneuropathy in Boy with Pituitary Dwarfism Treated with Recombinant Growth Hormone.

Papillary Carcinoma of Thyroid Gland in a Patient Treated with Recombinant Growth Hormone

The first successful treatment of growth hormone (GH) deficient children with GH extracted from human pituitary was introduced during late 1950's.  The subsequent availability and use of recombinant GH (rhGH) for different clinical conditions raised the question of whether this new therapeutic modality increases the risk of certain conditions such as leukemia or malignancy.  Herein, we report o...

The effect of pituitary growth hormone in dwarfism with osseous retardation and hypoglycemia and in a cretin treated with thyroid.

Neoplasms in rats treated with pituitary growth hormone.

The multiplicity and diversity of neoplasms in normal adult female rats injected for long periods with pituitary growth hormone have been pre viously reported (2-5). This paper is concerned with the absence of such tumors in hypophysec tomized rats similarly treated with growth hormone. A group of adult female rats of the Long-Evans strain, 148-237 days of age, was hypophysectomized. These anim...

Treatment of pituitary dwarfism with methionyl human growth hormone in Japan.

Sixty-two patients with pituitary dwarfism were treated with three different preparations of methionyl hGH (m-hGH) for 3 to 14 months. They were given 0.5 IU/kg/week intramuscularly. The growth rate during treatment with the three different preparations was the same for each and increased from 3.5 +/- 0.9 to 8.2 +/- 1.7 cm/year. A high incidence of hGH antibody formation was observed following ...

Long term effects of human growth hormone on 1,959 patients with pituitary dwarfism throughout Japan.

The results of 6 months to 8 years of treatment of pituitary dwarfism in 1,959 patients in Japan were summarized. The data were based on the reports of the physicians treating the patients. Among the patients, 1,720 cases suffered from idiopathic pituitary dwarfism, 227 cases from secondary pituitary dwarfism, and 12 cases from unknown causes. Their initial age ranged from 9 months to 36 years ...